The number one denotes absolute singleness.
“Hear, O Israel: The Lord our God, the Lord is one.” (Deuteronomy 6:4)
The number two symbolizes witness and support.
Two are better than one because they have a good reward for their toil. (Ecclesiastes 4:9)
The number three signifies completion or perfection, and unity. Three Persons are in the Trinity.
Jesus answered them, “Destroy this temple, and in three days I will raise it up.” (John 2:19)
The number four relates to the earth.
He will … gather the dispersed of Judah from the four corners of the earth. (Isaiah 11:12)
Five is a number associated with grace.
… Benjamin’s portion was five times as much as any of theirs. And they drank and were merry with him. (Genesis 43:34)
Six is the number of man.
“The cities that you give to the Levites shall be the six cities of refuge, where you shall permit the manslayer to flee …” (Numbers 35:6)
Seven refers to the number of God, divine perfection, or completeness.
When you buy a Hebrew slave, he shall serve six years, and in the seventh he shall go out free, for nothing. (Exodus 21:2, ESV)
The number eight signifies new beginnings.
Eight days later, his disciples were inside again, and Thomas was with them. Although the doors were locked, Jesus came and stood among them and said, “Peace be with you.” (John 20:26)
The number nine may mean fullness of blessing, although many scholars don’t assign any special meaning to this number.
The number ten relates to human governments and law.
And he [Boaz] took ten men of the elders of the city [as judges] and said, “Sit down here.” So, they sat down. (Ruth 4:2)
The number twelve relates to divine government, God’s authority, perfection, and completeness.
It [the New Jerusalem] had a great, high wall, with twelve gates, and at the gates twelve angels, and on the gates the names of the twelve tribes of the sons of Israel were inscribed… And the wall of the city had twelve foundations, and on them were the twelve names of the twelve apostles of the Lamb. (Revelation 21:12-14)
Thirty is a time frame and number associated with mourning and sorrow.
Then when Judas, his betrayer, saw that Jesus was condemned, he changed his mind and brought back the thirty pieces of silver to the chief priests and the elders, saying, “I have sinned by betraying innocent blood.” …And throwing down the pieces of silver into the temple, he departed, and he went and hanged himself. (Matthew 27:3-5)
Forty is a number associated with testing and trials.
Moses entered the cloud and went up on the mountain [Sinai]. And Moses was on the mountain forty days and forty nights. (Exodus 24:18)
The number fifty holds significance in feasts, celebrations, and ceremonies.
And you shall consecrate the fiftieth year, and proclaim liberty throughout the land to all its inhabitants. It shall be a jubilee for you… (Leviticus 25:10)
The number seventy is tied to judgment and human delegations.
And before them stood seventy men of the elders of the house of Israel… (Ezekiel 8:11)
666 is the number of the beast. The number or Mark of the Beast is the sign of the Antichrist (Revelation 13:15-18).